Perrier Lab – University of Copenhagen

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CNS > Research > Section for Molecular and Cellular Neuroscience > Perrier Lab

Perrier Lab

My lab has long-standing expertise in studying how the intrinsic properties of individual cells contribute to the behavior of networks. We always focus on the physiological relevance of our projects.

We have been studying how the monoamine serotonin modulates neurons. By means of patch-clamp recording, pharmacology, voltammetry and calcium imaging in slice and integrated preparations, we have demonstrated that serotonin provides helps the production of movements by modulating several voltage-gated conductances in the membrane of motoneurons (reviewed by Perrier and Cotel, 2015).

We provided the first demonstration of a functional modulation of the axon initial segment and thereby elucidated the cellular mechanism responsible for central fatigue (Cotel et al., PNAS 2013). These results obtained in vitro were recently confirmed in human beings (D’amico et al., JPhysiol 2017).

We are also studying how glial cells contribute to the production of movement by combining calcium imaging obtained with a multiphoton microscope and electrophysiology. We found that astrocytes inhibit synaptic transmission in a neuronal network responsible for the production of movement (Carlsen and Perrier, 2014). Our preliminary results suggest that this modulation regulates motor tremor.

We are also studying the properties of neurons from the hippocampus and recently discovered a pathway that can prevent the occurrence of temporal lobe epilepsy (Petersen et al., 2017).

Recent key publications

  • Petersen AV, Cotel F, Perrier JF. (2017). Plasticity of the Axon Initial Segment: Fast and Slow Processes with Multiple Functional Roles. Neuroscientist, in press.
  • Petersen AV, Jensen CS, Crépel V, Falkerslev M, Perrier JF (2017). Serotonin Regulates the Firing of Principal Cells of the Subiculum by Inhibiting a T-type Ca2+ Current. Frontiers in Cellular Neuroscience 11
  • D'amico JM, Butler AA, Héroux ME, Cotel F, Perrier JF, JE Butler JE, Gandevia SC, Taylor JL. Human motoneurone excitability is depressed by activation of serotonin 1A receptors with buspirone. The Journal of physiology 595 (5), 1763-1773
  • Perrier JF, Cotel F (2015). Serotonergic modulation of spinal motor control. Current Opinion of Neurobiology, 33: 1-7.
  • Cotel F, Exley R, Cragg SJ, Perrier JF (2013). Serotonin spillover onto the axon initial segment of motoneurons induces central fatigue by inhibiting action potential initiation. Proc Natl Acad Sci U S A. 110(12):4774-9.

Publication metrics (March 2017): Number of peer reviewed papers: 39;  Citations: 1037; H index: 18;  i10-index: 24