Dreyer Lab – University of Copenhagen

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CNS > Research > Section for Molecular and Cellular Neuroscience > Dreyer Lab

Dreyer Lab

Main projects in bullet points:

  • Computational Modeling of dopamine neurotransmission
  • Computational Modeling of Parkinson’s disease
  • Computation modeling of goal oriented behavior

Consequently there is no consensus on how DA cell firing mediates a relevant signal to post synaptic targets. I am developing a computational model of dopaminergic neurotransmission that provides a consistent integrated interpretation of DA signaling. It is fully constrained by anatomical and biophysical reality, tested experimentally, and thus provides a good candidate for a future unified framework for signaling by neuromodulators.

My model provides one of the best arguments that the celebrated minute variations in DA firing rate by unpredicted rewards observed by Wolfram Schultz provide a meaningful temporal signal and it provides groundbreaking new insights into the link between loss of dopamine neurons and symptoms in Parkinson’s disease.

Key publications:

  • Dodson, P.D., Dreyer, J.K., […],  Magill, P.J. (2016). Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism. PNAS. 113.
  • Dreyer, J.K., Vander Weele, C.M., Lovic, V., and Aragona, B.J. (2016). Functionally Distinct Dopamine Signals in Nucleus Accumbens Core and Shell in the Freely Moving Rat. J Neuroscience 36, 98-112.
  • Navntoft, C.A., and Dreyer, J.K. (2016). How compensation breaks down in Parkinson's disease: Insights from modeling of denervated striatum. Movement Disorders 31, 280-289
  • Dreyer, J.K. (2014). Three Mechanisms by which Striatal Denervation Causes Breakdown of Dopamine Signaling. J Neuroscience 34
  • Dreyer, J.K., Herrik, K.F., Berg, R.W., and Hounsgaard, J.D. (2010). Influence of phasic and tonic dopamine release on receptor activation. J Neuroscience 30, 14273-14283

Overall publication metrics:         14 papers, H index 7 (Scopus)

Patents: The use of dopamine D2 receptor antagonists for treatment of Parkinson’s disease and related disorders. Christiansen, Navntoft, Woldbye, Dreyer. Priority application #16164686.4-1453. April 11, 2016