Gjedde Lab – University of Copenhagen

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CNS > Research > Section for Integrative Neuroscience > Gjedde Lab

Gjedde Lab

The group’s research focuses on the relations between neuroplasticity and neurotransmission, as revealed by mapping radioligand binding and the neuroplastic changes of brain functions.

The investigations explore the relation between energy metabolism and neurotransmission by recording the changes of energy metabolism and consciousness under pharmacological and other manipulations.

The group uses PET to understand

1) the synthesis of radioligand and tracer molecules that match the neurotransmitter molecules and the behavior of these transmitters under different functional conditions of the brain, normal as well as pathological, and

2) the spatial and temporal relations among changes of cerebral blood flow, which is commonly used as a measure of brain work, and the cerebral consumption rates of glucose and oxygen, which are the more precise measures of total and aerobic glycolysis fractions.

The groups collaborations focus on experiments with volunteer subjects and patients that explore the changes associated with aging, as well as the lesions and degeneration of brain tissue in disorders such as epilepsy, Alzheimer’s and Parkinson's diseases, stroke, depression, and somatization disorders, as well as disorders related to addiction, both behavioral and pharmacological.

Experiments explore the restructuring of neuronal networks that follows when sensory activity is processed by healthy subjects or volunteers suffering from inborn or acquired lesions.

Key publications last 10 years

  • Aanerud J, Borghammer P, Rodell A, Jónsdottir KY, Gjedde A. Sex differences of human cortical blood flow and energy metabolism. J Cereb Blood Flow Metab. 2016 Jan 1:271678X16668536.
  • Hyder F, Herman P, Bailey CJ, Møller A, Globinsky R, Fulbright RK, Rothman DL, Gjedde A. Uniform distributions of glucose oxidation and oxygen extraction in gray matter of normal human brain: No evidence of regional differences of aerobic glycolysis. J Cereb Blood Flow Metab. 2016 May;36(5):903-16.
  • Stender J, Kupers R, Rodell A, Thibaut A, Chatelle C, Bruno MA, Gejl M, Bernard C, Hustinx R, Laureys S, Gjedde A. Quantitative rates of brain glucose metabolism distinguish minimally conscious from vegetative state patients. J Cereb Blood Flow Metab. 2015 Jan;35(1):58-65.
  • Gjedde A, Aanerud J, Braendgaard H, Rodell AB. Blood-brain transfer of Pittsburgh compound B in humans. Front Aging Neurosci. 2013 Nov 7;5:70.
  • Gejl M, Egefjord L, Lerche S, Vang K, Bibby BM, Holst JJ, Mengel A, Møller N, Rungby J, Brock B, Gjedde A. Glucagon-like peptide-1 decreases intracerebral glucose content by activating hexokinase and changing glucose clearance during hyperglycemia. J Cereb Blood Flow Metab. 2012 Dec;32(12):2146-52.
  • Aanerud J, Borghammer P, Chakravarty MM, Vang K, Rodell AB, Jónsdottir KY, Møller A, Ashkanian M, Vafaee MS, Iversen P, Johannsen P, Gjedde A. Brain energy metabolism and blood flow differences in healthy aging. J Cereb Blood Flow Metab. 2012 Jul;32(7):1177-87.
  • Gjedde A, Kumakura Y, Cumming P, Linnet J, Møller A. Inverted-U-shaped correlation between dopamine receptor availability in striatum and sensation seeking. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3870-5.

Overall publication metrics: Number of full papers listed in PubMed: 382; H-index: 80; i10-index: 298